An Improved Modeling of Parkinson’s Tremor and Investigation of Some Approaches to Remove this Symptom

In this research, an improved model of Parkinsonian tremor is presented by using a mathematical and computational approach. Parkinson’s disease (PD), abnormal signal produced basal ganglia (BG). This goes to the thalamus, then enters cortex after interaction with peripheral system muscle finally appears as tremor. model, all mentioned process are simulated. Also, skeletal well central nervous (basal ganglia, supplementary motor area) (spinal reflex) mechanisms considered. addition, two methods for suppression applied in paper, 1) deep brain stimulation (DBS) which affects dopamine level BG 2) mechanical method based on negative feedback. The accuracy efficiency simulation demonstrated comparison obtained results those clinical tests.